Elimination of cervical cancer in Tanzania: Modelled analysis of elimination in the context of endemic <scp>HIV</scp> infection and active <scp>HIV</scp> control

The World Health Organisation (WHO) has launched a strategic initiative for cervical cancer (CC) elimination which involves scaling up three interventions: human papillomavirus (HPV) vaccination, twice-lifetime HPV-screening screening and pre-cancer/cancer treatment by 2030. CC is challenging to control in countries with endemic immunodeficiency virus (HIV), as women living HIV (WLHIV) are at elevated risk of HPV infection, persistence progression. This analysis estimated the impact interventions on incidence mortality but additionally considered more intensive WLHIV, using Tanzania an example. A dynamic HIV/HPV model was used simulate strategy treatment, 3-yearly WLHIV starting age 25 years, context sustained from 2020 2119. Without vaccination or screening, rates per 100 000 predicted fall 58.0 41.6 (range: 39.1-44.7) 2119, due existing control. general population would reduce 1.3 1.3-2.5) (<4/100 000) 2076 2076-2092). reach 1.1 1.1-2.1) further reductions contingent increased access. Vaccination achieve subgroup potentially early 2061 2061-2078), 2119 rate 1.7 1.7-3.3). Scaling-up will substantially Tanzania, within century. Three-yearly high coverage rates, facilitate among thus accelerate overall population.